Local Anaesthetics (LA)
Mechanism of action - Bind to sodium channels to block transmission of action potentials They also bind to potassium and calcium channels...
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robinapark
Feb 15, 20213 min read
Ketamine. Just the need to know.
Mechanism of action (1) Non-competitive antagonist at phencyclidine binding site of N-methyl-D-aspartate (NMDA) in the CNS (particularly...
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robinapark
Feb 15, 20212 min read
Cannabis. Just what you need.
Notes from SA FPM Lecture: - Endocannabinoidome - Gut/brain axis - best described system - Phytocannabinoids - THC, Cannabidiol (but...
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robinapark
Feb 13, 202112 min read
Opioid Wisely!
Contents With respect to Curriculum 2020 - 2.1.26, 3.2.6, 3.4.9, 3.4.12 Mechanism of action of opioids Details of specific opioids...
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robinapark
Feb 11, 20213 min read
Tricyclic antidepressants (TCA's). Need to know.
Interesting history - They were introduced in diabetic neuropathy around 30 years ago - It has been shown repeatedly that these work not...
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robinapark
Feb 10, 20211 min read
Tapentadol
- Synthetic phenylpropylamine opioid - Has weak mu-receptor activity and inhibits reuptake of noradrenaline - Noradrenaline effects...
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robinapark
Feb 10, 20211 min read
Buprenorphine
Details: - Semi-synthetic - Partial mu-receptor agonist - Kappa-opioid ANTAgonist and agonist at opioid-receptor-like receptors (ORL-1) -...
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robinapark
Feb 4, 20212 min read
Lignocaine
Questions 1. Write short notes on the pharmacology and side effects of local anaesthetic agents. Attempted by 20 candidates PASS RATE 95...
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robinapark
Jan 27, 20212 min read
Analgesia in renal impairment
Remember the 5 phrases of pain management: By mouth (Avoid haemodialysis (HD) IV route unless critical) By the clock (Consider dosing...
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robinapark
Jan 25, 20212 min read
General Analgesic Pharmacology / Location of action
Peripheral: Capsaicin - Initial overstimulation of nociceptors leading to a period of insensitivity - Agonist at TRPV1 receptors -...
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robinapark
Jan 21, 20211 min read
Ketamine. Need to know.
https://journals.lww.com/painrpts/Fulltext/2018/10000/Ketamine_for_pain_management.7.aspx https://www.ncbi.nlm.nih.gov/pmc/articles/PMC61...
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robinapark
Jan 21, 20211 min read
Tricyclic antidepressants (TCA's). Need to know.
Mechanism of action Indications Dosing Common side effects Rare side effects - be aware! Liver and kidney issues? Golden pearls
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robinapark
Jan 21, 20211 min read
Opiate switching
Evidence - Up to 80% of patients achieve a successful outcome after switching! https://www.ncbi.nlm.nih.gov/pubmed/19345298/ Who to...
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robinapark
Jan 21, 20211 min read
Pregabalin - Need to know.
Mechanism of action - Analog of neurotransmitter GABA - Binds the alpha-2delta unit of calcium channels reducing calcium influx - Causes...
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robinapark
Jan 20, 20214 min read
Morphine - Need to know.
Pharmacology 4,5 Epoxymophinan ring = Morphine, codeine, oxymorphone, oxycodone, buprenorphine, hydromorphone, and hydrocodone....
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