Mechanism of action - Bind to sodium channels to block transmission of action potentials They also bind to potassium and calcium channels...

Mechanism of action (1) Non-competitive antagonist at phencyclidine binding site of N-methyl-D-aspartate (NMDA) in the CNS (particularly...

Notes from SA FPM Lecture: - Endocannabinoidome - Gut/brain axis - best described system - Phytocannabinoids - THC, Cannabidiol (but...

Contents With respect to Curriculum 2020 - 2.1.26, 3.2.6, 3.4.9, 3.4.12 Mechanism of action of opioids Details of specific opioids...

Interesting history - They were introduced in diabetic neuropathy around 30 years ago - It has been shown repeatedly that these work not...

- Synthetic phenylpropylamine opioid - Has weak mu-receptor activity and inhibits reuptake of noradrenaline - Noradrenaline effects...

Details: - Semi-synthetic - Partial mu-receptor agonist - Kappa-opioid ANTAgonist and agonist at opioid-receptor-like receptors (ORL-1) -...

Questions 1. Write short notes on the pharmacology and side effects of local anaesthetic agents. Attempted by 20 candidates PASS RATE 95...

Remember the 5 phrases of pain management: By mouth (Avoid haemodialysis (HD) IV route unless critical) By the clock (Consider dosing...

Peripheral: Capsaicin - Initial overstimulation of nociceptors leading to a period of insensitivity - Agonist at TRPV1 receptors -...

https://journals.lww.com/painrpts/Fulltext/2018/10000/Ketamine_for_pain_management.7.aspx https://www.ncbi.nlm.nih.gov/pmc/articles/PMC61...

Mechanism of action Indications Dosing Common side effects Rare side effects - be aware! Liver and kidney issues? Golden pearls

Evidence - Up to 80% of patients achieve a successful outcome after switching! https://www.ncbi.nlm.nih.gov/pubmed/19345298/ Who to...

Mechanism of action - Analog of neurotransmitter GABA - Binds the alpha-2delta unit of calcium channels reducing calcium influx - Causes...

Pharmacology 4,5 Epoxymophinan ring = Morphine, codeine, oxymorphone, oxycodone, buprenorphine, hydromorphone, and hydrocodone....